Association between the dynamics of the gut microbiota and responsiveness to mental health therapy

Abstract Growing evidence suggests that the intestinal microbiota may influence brain activity through metabolites and/or inflammation, but it is unclear whether impact of psychological interventions such as meditation connected to dynamics gut microbiota. In presented study, we collected and plasma cytokine, chemokine, growth factor data from a longitudinal cohort 52 people (142 multi-omics samples) before, during, after nine-day meditation. We identified strong relationship between mental health status composition High level bacteria genus Prevotellais correlated with improved effects in stressed persons. addition, number inflammatory cytokines, GROA, are significantly reduced Prevotella-dominating individuals. Following nine days meditation, there decrease pro-inflammatory an increase relative abundance Prevotella, improvement individual’s measurements. Our study provides novel link towards possibility affects stress regulating cytokines.